Dominantly inherited, present before age 1. Asymptomatic until later in life; irritation, photophobia, RCEs |
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Meesmann's Dystrophy (epithelium) |
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Dominantly inherited, present before age 1. Asymptomatic until later in life; irritation, photophobia, RCEs |
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Meesmann's Dystrophy (epithelium) |
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Dominantly inherited, present before age 1. Asymptomatic until later in life; irritation, photophobia, RCEs |
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Meesmann's Dystrophy (epithelium) |
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Dominantly inherited, present before age 1. Asymptomatic until later in life; irritation, photophobia, RCEs |
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Meesmann's Dystrophy (epithelium) |
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After age 40; bilateral; can be auto-dominant; ghost images, irregular astigmatism, RCEs, visual distortion |
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Map-Dot-Fingerprint dystrophy (epithelium) |
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After age 40; bilateral; can be auto-dominant; ghost images, irregular astigmatism, RCEs, visual distortion |
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Map-Dot-Fingerprint dystrophy (epithelium) |
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After age 40; bilateral; can be auto-dominant; ghost images, irregular astigmatism, RCEs, visual distortion |
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Map-Dot-Fingerprint dystrophy (epithelium) |
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After age 40; bilateral; can be auto-dominant; ghost images, irregular astigmatism, RCEs, visual distortion |
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Map-Dot-Fingerprint dystrophy (epithelium) |
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First decade; autosomal dominant; decreased corneal sensitivity, frequent RCEs |
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Reis-Buckler Dystrophy or Thiel-Behnke Dystrophy (more honeycombish) - Bowman's layer |
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First decade; autosomal dominant; decreased corneal sensitivity, frequent RCEs |
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Reis-Buckler Dystrophy or Thiel-Behnke Dystrophy (more honeycombish) - Bowman's layer |
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First decade; autosomal dominant; decreased corneal sensitivity, frequent RCEs |
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Reis-Buckler Dystrophy or Thiel-Behnke Dystrophy (more honeycombish) - Bowman's layer |
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1st-2nd decade; autosomal dominant; starts unilateral becomes bilateral; decreased corneal sensation |
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Schnyder's Crystaline dystrophy - Bowman's and stroma affected |
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1st-2nd decade; autosomal dominant; starts unilateral becomes bilateral; decreased corneal sensation |
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Schnyder's Crystaline dystrophy - Bowman's and stroma affected |
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1st-2nd decade; autosomal dominant; starts unilateral becomes bilateral; decreased corneal sensation |
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Schnyder's Crystaline dystrophy - Bowman's and stroma affected |
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1st-2nd decade; autosomal dominant; starts unilateral becomes bilateral; decreased corneal sensation |
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Schnyder's Crystaline dystrophy - Bowman's and stroma affected |
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Appears before adolescence; Sx by 40; Autosomal dominant and bilateral; RCEs, photophobia, deteriorating vision |
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Granular (Bread crumb) dystrophy; Groenouw Type 1; very common. Peripheral 2-3 mm never involved (ddx from macular dystrophy) (stroma) |
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Appears before adolescence; Sx by 40; Autosomal dominant and bilateral; RCEs, photophobia, deteriorating vision |
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Granular (Bread crumb) dystrophy; Groenouw Type 1; very common. Peripheral 2-3 mm never involved (ddx from macular dystrophy) (stroma) |
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Appears before adolescence; Sx by 40; Autosomal dominant and bilateral; RCEs, photophobia, deteriorating vision |
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Granular (Bread crumb) dystrophy; Groenouw Type 1; very common. Peripheral 2-3 mm never involved (ddx from macular dystrophy) (stroma) |
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Appears before adolescence; Sx by 40; Autosomal dominant and bilateral; RCEs, photophobia, deteriorating vision |
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Granular (Bread crumb) dystrophy; Groenouw Type 1; very common. Peripheral 2-3 mm never involved (ddx from macular dystrophy) (stroma) |
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Appears before adolescence; Sx by 40; Autosomal dominant and bilateral; RCEs, photophobia, deteriorating vision |
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Granular (Bread crumb) dystrophy; Groenouw Type 1; very common. Peripheral 2-3 mm never involved (ddx from macular dystrophy) (stroma) |
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Appears before adolescence; Sx by 40; Autosomal dominant and bilateral; RCEs, photophobia, deteriorating vision |
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Granular (Bread crumb) dystrophy; Groenouw Type 1; very common. Peripheral 2-3 mm never involved (ddx from macular dystrophy) (stroma) |
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Appears before adolescence; Sx by 40; Autosomal dominant and bilateral; RCEs, photophobia, deteriorating vision |
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Granular (Bread crumb) dystrophy; Groenouw Type 1; very common. Peripheral 2-3 mm never involved (ddx from macular dystrophy) (stroma) |
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Before age 10; Autosomal dominant; decreased vision and RCEs, marked decreased corneal sensitivity in 3rd decade |
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Lattice Dystrophy type 1: no systemic involvement (stroma) |
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After age 20; Autosomal dominant; Dutch/ Finnish/ Schottish; few RCEs, decreased vision in 60s |
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Lattice dystrophy type 2 (in Meratoja syndrome - systemic familial amyloidosis): fewer lines in periphery (stroma) |
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Onset after age 40; Autosomal recessive, Japanese; visual decrease by 60, no RCEs |
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Lattice dystrophy type 3: thicker lattice lines (stroma) |
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1st decade; autosomal recessive, poor vision by age 20; high photophobia and few RCEs, central corneal thinning and dec sensitivity |
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Macular dystrophy (Groenouw type 2), uncommon (stroma) |
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1st decade; autosomal recessive, poor vision by age 20; high photophobia and few RCEs, central corneal thinning and dec sensitivity |
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Macular dystrophy (Groenouw type 2), uncommon (stroma) |
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1st decade; autosomal recessive, poor vision by age 20; high photophobia and few RCEs, central corneal thinning and dec sensitivity |
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Macular dystrophy (Groenouw type 2), uncommon (stroma) |
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1st decade; autosomal recessive, poor vision by age 20; high photophobia and few RCEs, central corneal thinning and dec sensitivity |
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Macular dystrophy (Groenouw type 2), uncommon (stroma) |
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autosomal dominant, asymmetric; no decrease in vision; decreased corneal sensation, VERY photophobic |
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Fleck Dystrophy of Francois-Neeten, stroma |
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autosomal dominant, asymmetric; no decrease in vision; decreased corneal sensation, VERY photophobic |
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Fleck Dystrophy of Francois-Neeten, stroma |
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Women; after 5-6th decade; can be auto dominant, pt asymptomatic, bilateral but asymmetric |
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Stage 1 Fuch's Endothelial dystrophy; guttata |
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Women; after 5-6th decade; can be auto dominant, pt asymptomatic, bilateral but asymmetric |
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Stage 1 Fuch's Endothelial dystrophy; guttata give classic beaten metal appearance |
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Women; after 5-6th decade; can be auto dominant, blurred vision & glare worse in morning, loss of corneal sensation, FB sensation, RCEs |
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Stage 2 Fuch's endothelial dystrophy, bilateral but asymmetric |
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Women; after 5-6th decade; can be auto dominant, blurred vision & glare worse in morning, loss of corneal sensation, FB sensation, RCEs |
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Stage 2 Fuch's endothelial dystrophy, bilateral but asymmetric |
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Women; after 5-6th decade; can be auto dominant, blurred vision & glare worse in morning, loss of corneal sensation |
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Stage 3 Fuch's endothelial dystrophy; pannus and neovascularization, bilateral but asymmetric |
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Women; after 5-6th decade; can be auto dominant, blurred vision & glare worse in morning, loss of corneal sensation |
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Stage 3 Fuch's endothelial dystrophy; pannus and neovascularization, bilateral but asymmetric |
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What does this slide demonstrate? |
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Polymegathism and polymorphism in Fuch's enothelial dystrophy |
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Begins early and progresses slowly; bilateral; no Sx; auto Dominant |
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Posterior Polymorphous Dystrophy |
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Begins early and progresses slowly; bilateral; no Sx; auto Dominant |
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Posterior Polymorphous Dystrophy |
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Begins early and progresses slowly; bilateral; no Sx; auto Dominant |
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Posterior Polymorphous Dystrophy |
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Auto dom occurs within first 3 years, photophobic and ocular pain, deafness; auto rec is born with opacity and develop nystagmus |
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Congenital hereditary endothelial dystrophy: note hudson stahli line |
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Auto dom occurs within first 3 years, photophobic and ocular pain, deafness; auto rec is born with opacity and develop nystagmus |
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Congenital hereditary endothelial dystrophy: note hudson stahli line |
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Young males, usually bilateral, painless, progressive AR astigmatism |
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Terrien's marginal degeneration |
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Young males, usually bilateral, painless, progressive AR astigmatism |
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Terrien's marginal degeneration |
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Age 20-40, bilateral, AR astigmatism, assoc w/KC |
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Pellucid marginal degeneration |
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Age 20-40, bilateral, AR astigmatism, assoc w/KC |
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Pellucid marginal degeneration |
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Age 20-40, bilateral, AR astigmatism, assoc w/KC |
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Pellucid marginal degeneration |
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Age 20-40, bilateral, AR astigmatism, assoc w/KC |
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Pellucid marginal degeneration |
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Elderly, no sx, can be idiopathic or assoc w/RA, lupus and many others |
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Senile Furrow Degeneration |
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Uni or bilateral, males, China/Africa, painful, assoc w/ parasite/microbial infxn, trauma, chemical burns |
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Mooren's Ulcer |
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Uni or bilateral, males, China/Africa, painful, assoc w/ parasite/microbial infxn, trauma, chemical burns |
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Mooren's Ulcer |
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Uni or bilateral, males, China/Africa, painful, assoc w/ parasite/microbial infxn, trauma, chemical burns |
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Mooren's Ulcer |
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Women age 30-50, unilateral, 100% develop glaucoma |
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Chandler's syndrome (ICE) - endothelial atrophy, corneal edema |
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Women age 30-50, unilateral, 100% develop glaucoma |
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Chandler's syndrome (ICE) - endothelial atrophy, corneal edema |
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Women age 30-50, unilateral, 100% develop glaucoma |
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Essential Iris Atrophy (ICE) - endothelial proliferation into angle |
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Women age 30-50, unilateral, 100% develop glaucoma |
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Cogan-Reese syndrome (ICE) - iris stromal atrophy, iris nodules and whorl pattern |
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Any age, but usually females over age 50, 80% bilateral, history of chronic inflammation or trauma, asymptomatic or minor irritation/blur |
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Salzmann's Nodular degeneration - bluish grey elevated nodules located in superficial stroma |
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Any age, but usually females over age 50, 80% bilateral, history of chronic inflammation or trauma, asymptomatic or minor irritation/blur |
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Salzmann's Nodular degeneration - bluish grey elevated nodules located in superficial stroma |
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Aging, actinic exposure, men |
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Spheroidal degeneration (type 1) [type 2 assoc w/trauma, type 3 assoc w/conj and pinguecula] |
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Aging, actinic exposure, men |
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Spheroidal degeneration (type 1) [type 2 assoc w/trauma, type 3 assoc w/conj and pinguecula] |
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Present at birth, bilateral, can be auto dominant, early cataracts and 50% develop glaucoma |
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Posterior embryotoxin and iris processes - together called Axenfeld's anomaly (axenfeld's syndrome includes presence of glaucoma) |
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Present at birth, bilateral, can be auto dominant, early cataracts and 50% develop glaucoma |
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Rieger's anomaly - iris stromal hypoplasia. Can be with or without glaucoma, and also can present w/ corectopia or pseudopolycoria |
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Present at birth, bilateral, can be auto dominant, early cataracts and 50% develop glaucoma |
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Rieger's anomaly - iris stromal hypoplasia, corectopia |
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Present at birth, bilateral, can be auto dominant, early cataracts and 50% develop glaucoma |
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Rieger's anomaly - iris stromal hypoplasia, corectopia, ectropion uveae |
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Present at birth, bilateral, can be auto dominant, early cataracts and 50% develop glaucoma |
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Rieger's anomaly - iris stromal hypoplasia, corectopia, pseudopolycoria |
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