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Cards In This Set
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OxPhos is the major process for formation
of what?
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OxPhos is major process for formation of
ATP in most cells
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OxPhos is divided into 2 processes. what
are they?
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(1) exergonic electron transport from
NADH + H and FADH2 to O2 via
intermediate carriers
(2) endergonic syn of ATP
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______ is the terminal electron acceptor to yield _____
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O2 is the terminal electron acceptor to yield H2O
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What are the 2 waste products of cellular respiration?
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CO2 and H2O
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Where are electrons passed thru redox carriers?
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Inner mitochondrial membrane
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As electrons pass thru redox carriers in the inner mitochondrial membrane, what happens to protons?
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They move outward, creating a gradient. re-entry of protons thru pore in ATP synthase drives ATP syn
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What are the 2 components of OxPhos regulation?
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(1) energy need
(2) availability of ADP & Pi
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Describe permeabilities of the inner and outer mitochondrial membranes
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Outer membrane: permeable to anions & small molecules
inner membrane: impermeable to almost everything
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What 2 things are embedded in teh inner mitochondrial membrane?
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(1) protein complexes/ electron carriers
(2) ATP synthase (projects inot matrix to generate ATP)
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Is the ETC energetically favorable or unfavorable? how many ATP molecules are syn'd from NADH?
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Energetically FAVORABLE
3 ATP molecules are syn'd
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Name the 6 enzymes & electron carriers of ETC
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(1) NADH DHD
(2) Coenzyme Q (3) Complex II (4) Cytochrome b-c1 (5) cytochrome c (6) cytochrome oxidase (complex IV) |
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Describe NADH DHD (related complex, components, what do components accept?)
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(1)NADH DHD is a huge complex (COMPLEX I)
(2) has FMN + Fe-S centers
(3) FMN accepts e's from NADH and sends them to Fe-S centers
(4)NADH oxidized to NAD
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What happens to teh electrons that were passes to Fe-S centers by FMN in complex I?
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They are given to coenzyme Q
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What is significant about CoQ?
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It is NOT protein bound, so it is freely moveable
(2) diffuses thru lipids of inner mitoch membrane
(3) red/ox of CoQ associated with transmembrane movement, this is part of proton pumping
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Complex II conencts what to what?
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Complex II (succindate DHD) connects respiratory chain of inner mitoch membrane with TCA cycle enzymes in mitochondrial matrix
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