+
Related Flashcards
Related Topics
Cards In This Set
| Front | Back |
|
Missense vs. nonsense mutation
|
An amino acid is replaced by another AA vs. a stop codon
|
|
Coalescence
|
All lines of descent eventually converge on a signle copy of the gene if we trace back a population far enough
|
|
Autosomes
|
Non-sex chromosomes
|
|
Orthologs
|
Type of homologl; different species with common ancestor; single gene divergence
|
|
Random drift
|
The process by which random mutations are spread throughout the population.
u fix=Nu x pfix = u where u is the prob a new mut. arising at each site in a DNA seq in a generation |
|
Polymorphic
|
Many proteins from different individuals have alternative alleles, meaning their loci are _____. Protein loci can be this as well as DNA loci.
|
|
Transposon
|
DNA sequence that can change its position within the genome, sometimes creating or reversing mutations and altering the cell's genome size.
|
|
Translocation
|
Caused by the rearrangement of parts between nonhomologous chromosomes
|
|
Transversion
|
Substitution of a purine for a pyrimidine or vice versa. Tends to have drastic consequences.
|
|
NCBI GenBank
|
Archival nucleotide sequences. Has genes, mRNA, rRNA, etc. Raw data, may contain mistakes
|
|
NCBI RefSeq
|
Curated collection of DNA. RNA, and prot. sequences. Provides 1 example of each natural biological mc for major organisms
|
|
UniProt
|
Database of protein sequences; protein-centric info about gene product
|
|
Entrez
|
Search engine for NCBI website; system can provide views of gene and protein sequences, chromos. maps
|
|
NCBI databases
|
Conserved domains, Gene, OMIM (human genetic disorders), Structure
|
|
Signal peptide
|
Directs the secretion of retinol binding protein. After secretion, its cleaved to form the mature protein
|
