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Related Flashcards
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Cards In This Set
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Immunohematology
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The study of blood and blood forming tissue in relation to the immune response
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Blood Bank
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Facility that collects, tests, processes, stores and distributes blood components
-Main Goal:Provide quality services and safe blood products
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Transfusion services
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Facility (usually part of a hospital laboratory) that performs compatibility testing, storage, selection and issuing of blood products to intended recipients
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Routine Testing
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Blood type, Ab screening, crossmatch, DAT
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Reference Lab
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Problem solving, abnormal ABO/Rh type, ID of unexpected antibodies, difficult crossmatch
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Donor Center
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Screen/draw donors, collect and divide into components, store and ship
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Component Preparation
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Blood from donor center to divide into components
RBC, plasma (FFP), platelet concentrates
Patient only gets what he/she needs
One donation for >1 recipients
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Where are antibodies located?
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In the serum
(SERUM=ANTIBODY) |
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Where are antigens?
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Antigenic determinants are on RBCs
Patient’s or pooled human RBCs
(RBC'S=ANTIGEN) |
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Agglutination has 2 STEPS:
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1. Sensitization
Attachment of antigen to antibody
2. Agglutination
Lattice formation makes reaction visible
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Name two antibodie classes
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IgG and IgM
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Serum to cell ratio
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80:1 (is ideal)
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Site of antigens
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ABO antigens:
Protrude from RBC surface
Rh antigens:
Part of RBC membrane, therefore harder for antibody to attach
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What is dosage?
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Antibody reacts more strongly with homozygous cells than with heterozygous cells
Infrequent situation
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What does complement have to do with blood bank reactions?
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Antigen + antibody + complement=lysis rather than agglutination
-Lysis is also a positive reaction
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