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Cards In This Set
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What are inflammatory bowel diseases?
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Chronic inflammations of the gut not associated with infectious pathogens, drug/toxin exposures, ischemia
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What are the 2 major forms of IBD?
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1. Crohn's disease2. Ulcerative colitis
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The inflammation of IBD is due to ___________
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Dysfunction immune response to antigens in the intestine
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CD vs. UC - location
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CD = any part of GI tract, from mouth to anusUC = only in the colon
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CD vs. UC - distribution of lesions
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CD = skip lesionsUC = continuous lesions
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CD vs. UC - inflammation
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CD = transmural inflammation (includes mucosa, submucosa, and muscular layers)UC = superficial inflammation (mucosa and submucosa)
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CD vs. UC - lesions
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CD = focal lesions, granulomasUC = diffuse lesions
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T/F. When you talk to patients, you can distinguish CD from UC by symptoms.
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FALSE. Cannot distinguish the 2 by symptoms.
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Where does UC start?
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In the rectum (distally), and spreads up to proximal segments of the colon
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What are 3 common rectal symptoms associated with CD and UC?
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Urgency, frequency, incomplete evacuation of stool
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What is the major difference in presentation b/t UC and CD?
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UC is usu more abrupt in onset and involves more proctitic symptoms since it involves the rectum most severely.CD is usu more insiduous in onset and has less bloody diarrhea, etc. since it doesn't affect the rectum as severely.
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What is the clinical presentation of ulcerative colitis?
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DiarrheaHematocheziaTenesmusFeverWeight lossExtraintestinal manifestations
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What is the clinical presentation of Crohn's disease?
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DiarrheaAbdominal painWeight lossFeverPerianal diseaseBleedingExtraintestinal manifestations
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What are the clinical features of Crohn's disease?
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Chronic, relapsing, full-thickness inflammation of the gutAffects small bowel (30%), large bowel (30%), or both (40%)Fistulizations, strictures, abdominal pain, diarrhea, bleeding, weight loss, fever, lethargyExtraintestinal manifestations = uveitis, episcleritis, arthritis, oral ulcers, kidney stones, skin disease20% chronically active, 70% chronic relapsing, 10% in remission70% will require surgery
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What is the distribution of inflammation in Crohn's disease?
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In most cases, the inflammation is in the ileum/cecum (ileocolitis)This is followed by jejunoileitis/ileitis (small bowel only) and colitis (colon only) and gastroduodenitis (stomach/small bowel)
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