Define Following CYP450 and Pgp Substrates, Inhibitors, and Inducers Flashcards

The drug name is on one side and whether it is substrate, inducer, or inhibitor for specific CYP450 isoenzymes is on the back. If the drug was listed as both substrate and inhibitor, but it wasn't starred as a substrate then the inhibitor is in bold and that's all we need to know. Also, the subrates/inhibitors/inducers for pgp are included

88 cards   |   Total Attempts: 183
  

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Cards In This Set

Front Back
Caffeine
Substrate, CYP1A2
Clozapine
Substrate, CYP1A2, CYP3A4
Olanzapine
Substrate, CYP1A2
Theophylline
Substrate, CYP1A2
Clomipramine
Substrate, CYP1A2, CYP2C19, CYP3A4
Imipramine
Substrate, CYP1A2, CYP2C19, CYP3A4
Amitriptyline
Substrate, CYP1A2, CYP2C19, CYP3A4
R-Warfarin
Substrate, CYP1A2
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Haloperidol
Substrate, CYP1A2 Inhibitor, CYP2D6
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Fluvoxamine
Substrate, CYP1A2 Inhibitor, CYP1A2, CYP2C9/10
Phenytoin
Substrate, CYP2C9, CYP2C19 Inducer, CYP3A4
S-warfarin
Substrate, CYP2C9
Clotrimazole
Inducer for pgp