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GENERIC NAME:
BRAND NAME:
CLASS:
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Epinephrine
Adrenalin
Sympathomimetic
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MECHANISM OF ACTION:
1.
A.
B1.
B2
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Direct acting alpha and beta-agonist.
Alpha: Vasoconstriction.
Beta-1: +HR,+FOC,+CV effects.
Beta-2 smooth muscle dilation & relaxation
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INDICATIONS:
1.
2.
3.
4.
5.
6.
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Cardiac arrest.
symptomatic Bradycardia (dopamine), sever hypotension 2 to Bradycardia (atropine,pacing).allergic reactions,anaphylaxis,asthma
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CONTRAINDICATIONS:
1.
2.
3.
4.
5.
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Hypertension,
hypothermia,
pulmonary edema,
myocardial ischemia,
Hypovolemic shock.
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ADVERSE REACTIONS:
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
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Hypertension, tachycardia, arrhythmias, pulmonary edema, anxiety, restlessness, psychomotor agitation, nausea, headache, angina.
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NOTES ON ADMINISTRATION
1.
2.
3.
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Pregnancy safety; Category C. May cause syncope in asthmatic children. May increase myocardial oxygen demand.
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INCOMPATABILITIES/DRUG INTERACTIONS:
1.
2.
3.
4.
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Potentiates other sympathomimetics, deactivated by alkaline solutions (bicarb) MAOIs may potentiate effects, beta blockers may blunt effects.
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DOSE/ROUTE:
Adult:
allergic reactions and asthma:
Anaphylaxis:
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Allergic reactions & asthma: 0.3-0.5 mg 1:1000 SC.
Anaphylaxis: 0.1mg of 1:10,000 IV/IO over 5 minutes.
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DOSE/ROUTE:
Pediatric:
Allergic reactions and Asthma
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Allergic reactions and asthma: 0.01 mg/kg of 1:1,000 solution SC.
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ONSET OF ACTION
PEAK EFFECTS:
DURATION OF ACTION:
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Immediate.
Minutes.
Several minutes.
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DOSE/ROUTE:
Adult:
Cardiac arrest:
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IV/IO dose 1 mg of 1:10,000 every 3-5 minutes during resuscitation. Follow each dose with 20 mL flush and elevate arm for 10-20 secs.
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DOSE/ROUTE:
Pediatric:
Cardiac arrest:
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IV/IO dose 0.01 mg/kg of 1:10,000 solution every 3-5 minutes during arrest.
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Dose/Route:
Adult
What is the higher dose and what specific indications is it for?
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Up to 0.2mg/kg and may be used on beta blocker or calcium channel blocker OD.
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Dose/Route
Adult
Continuous infusion
How is it mixed and what rate is it administered.
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Add 1mg of 1:1000 to a 500ml bag of NS or D5W. Initial dose of 1mcg/min titrated to effect. Typical dose 2-10mcg/min
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Dose/Route
Adult
infusion for profound bradycardia, or hypotension.
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2-10mcg/min titrate to patient response.
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