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Cards In This Set
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Drug Class
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Sympathomimetic
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Mechanism of Action
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Direct acting alpah and beta agonist. Alpha: vasoconstriction. Beta-1: postive inotropic, chronotropic, and dromotropic effects. Beta-2: bronchial smooth muscle relation and dilation of skeletal vasculature. Blocks histamine receptors.
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How Supplied
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1:1,000 solution: Ampules and vials containing 1 mg/ml . 1:10,000 solution: Prefilled syringes containing 0.1 mg/ml. Auto injector (EpiPen): 0.5 mg/ml (1:2,000)
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Indications
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Cardiac arrest (asystole, PEA, ventricular)
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Contraindications
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Hypertension, Pulmonary edema
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Adverse Reactions / Side Effects
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Pulmonary edema, Chest pain
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Drug Interactions
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Potentiates other sympathomimetics. Deactivated by alkaline solutions. MAOIs may potentiate effect. Beta blockers may blunt effects.
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Dosage and Administration
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Mild allergic reactions and asthma: Adult; 0.3 - 0.5mg (0.3 - 0.5ml) of 1:1,000 solution IM/SC Pediatric: 0.01 mg/kg (0.01ml/kg) of a 1:1,000 solution SC (maxium 0.3mL) Anaphylaxis / Severe Status Asthmaticus: Adult; 0.1 mg (1mL) of 1:10,000 solution IV. Pediatric; 0.01mg/kg (0.01mL/kg) IM of a 1:1,000 solution (maximum single dose: 0.3mg) Symptomatic Bradycardia: IV/IO dose: 0.01 mg/kg (0.01 mL/kg) of a 1:10,000 solution
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Duration
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Onset:Immediate Peak Effect: Minutes Duration: Several minutes
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Special Considerations
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Pregnancy safety: Category C. May cause syncope in asthmatic children. May increase myocardial oxygen demand
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