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Cards In This Set
| Front | Back |
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Chromosomes are packed into ...
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CHROMATINS
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Chromatin made up of
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DNA + Protein (+ small amount of RNA)
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Chromatin has 2 types of protein:
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Histones and nonhistones
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Histones 5 classes
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Small basic proteins
H1 H2AH2BH3H4 |
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Nonhistones
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Different types of protein with different functions
structural, replication, specific transcription |
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Nucleosome
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Complex of DNA and histones
"core particle" |
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Nucleosome made up of..?
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8 proteins (OCTAMER)
H2A H2B H3 AND H4 (2 copies of each) |
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Solenoid
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30 nm chromatin fibers
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30 nm chromatin fibers provide .... fold packing
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100 fold packing
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30 nm chromatin fibers: (#) nucleosomes per turn of helix
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6
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H1 protein function?
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Fiber formation and packing.
one H1 binds to 1 nucleosome |
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Less H1 means
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High gene transcription and less ordered
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Topoisomerase
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Untangle DNA in an impotmum location to untwist DNA
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Nuclear scaffolding
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Made by packing 20 nm fibers on scaffold of NONHISTONE protein
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Centromere function 3
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Insure precise segregation of chromsomes
holds sister chromatids together site of microtubule attachment for separating chromatids during mitosis and meiosis |
