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| Front | Back |
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What are the two pathways for antigen presentation?
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1. Cytosolic
2. Endocytic |
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What are endogenous antigens? List 4 examples.
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Endogenous antigens are intracellular antigens.
1. Viruses 2. Cancer 3. Mycobacterium 4. Listeria |
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What are exogenous antigens? List 3 examples.
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Enxogenous antigens are extracellular antigens.
1. bacteria 2. fungi 3. parasites |
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Endogenous antigens are presented by the APC to the T cell by ________________.
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MHC Class I
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Exogenous antigens are presented by the APC to the T cell by ________________.
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MHC Class I I
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In the cytosolic pathway, endogenous antigens bind with 1.____________ and are delivered to
2.________ _________ __________ where it is broken down into 3._______________. |
1. ubiquitin enzymes
2. cytoplasmic proteosome complex 3. peptides |
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Exogenous antigens such as bacteria, fungi, or parasites are taken into the APC by 1. _________ or 2. ____________ and compartmentalized in 3.________.
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1. phagocytosis
2. endocytosis 3. endocytic vesicles |
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True or False. In the cytosolic pathway, ubquitin binds to the carboxyl group of the lysine side chain of the protein.
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False. Ubiquitin binds to the amino group on the lysine side chain.
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After ubiquitin is bound to the amino group of the lysine side chain via ubiquinating enzymes and ATP, it goes to the ___________ where proteolytic enzymes break it down into peptides.
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Proteasome
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In the cytosolic pathway, _______ transports antigenic peptides to the endoplasmic reticulum
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TAP
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In the cytosolic (endogenous) pathway, calnexin is broken down to
1. ____________ 2. ____________ |
 1. Calreticulin 2. beta 2 microglobulin |
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After endogenous antigens are compartmentalized in endocytic vesicles, what are the two processes that can occur?
1. _______________________ 2. _______________________ |
1. They are broken down further by exopepsidases into amino acids and secreted from the cell
2. Endocytic vesicles containing the peptides fuse with the endocytic vesicles that contain the MHC Class II |
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Beta 2 Microglobulin associates with the heavy chain of _____________.
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MHC Class I
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The peptides that associate with the cleft of MHC Class I are 1. ___ to 2. ___ amino acids in length.
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1. 9
2. 10 |
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The peptides that associate with the cleft of MHC Class II are 1. ___ to 2. ___ amino acids in length.
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1. 13
2. 15 |
