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Cards In This Set
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Where does marijuana come from?
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Cannabis sativa/indicaPotency depends on genetic history of plantActive drug is delta-9-tetrahydrocannabinolGenerally: cannabinols
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What is the ligand that THC mimics and what is its general class of molecules?
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Anandamide (anand=bliss in sanskrit)
Endocannabinoids |
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Harry Anslinger
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1932: Commissioner of narcotics (although weed not narcotic1937: All 48 states enact anti-weed lawsBy 1950: Weed made out to cause crazed violent behavior
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Generalized Marijuana history minus Harry Anslinger
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Major cash crop for hemp in textiles in the middle to late 1700s.Declined with growth of cotton as major cash crop of the American south
Now, against American way to smoke pot, become lazy, reduce productivity |
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Uses and effects of marijuana
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Medically:Reduces pressure from glaucomaIncreases appetite and decreases nausea in chemo patients
Negative:Impairs focus, attention, executive controlImpairs ability to operate heavy machineryInduces paranoia-- chronic marijuana use may increase chances of developing schizophrenia |
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Define: Gateway Drug
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A Gateway Drug is a "soft" drug that leads to "hard" drug use. Flawed because not known number of weed smokers that never use harder drugs.
Nicotine greater gateway |
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Marijuana Mechanism
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Glutamate binds to NMDA receptorNMDA receptor releases endocannabinoidsEndocannabinoids bind pre-synaptic CB1 receptorCB1 activation reduces glutamate releaseType of feedback inhibition.THC binds to CB1 and inhibits glutamate release
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How does THC impair memory formation?
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THC binds CB1 and impairs glutamate releaseGlutamate does not bind to NMDA receptor, no LTP and thus no memory formation
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