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Cards In This Set
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Placebo?
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A medication that contains no drug. Effects are dependent on mood, expectations and imagination.
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Concentration of Drug?
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The amount of moles in known volume
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Dose?
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The amount of drug administered.
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Magnitude of effect?
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Assumed to be directly proportional to the fraction of recpetors that are occupied (Y).E = maximal effect x Y
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Potency?
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The affinity of a drug for the receptor and measures the amount of drug needed for an effect.
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Efficacy?
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The measure of max effect that can be obatained form any dose.
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Slope?
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Slope of cureve, shows the speed of response. if steep samll increases in dose cause dramtic increases in effect.
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Therapeutic effect?
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A comparison of the amonut of drug that produces an effect and the amount that is lethal. The smaller the index, the smaller the difference between toxic and safe.
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Agonist?
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Ligand/drug that has affinity and efficacy for receptor. binds to receptor and drives to active form.
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Partial agonist?
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Has affinity but lower efficacy for receptor. In the presence of a full antagonist acts as a full agonist.
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Inverse agonist/negative antagonist?
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Has opposite effect to agonist, drives to inacitve form as higher affinity.
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Antagonist?
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Has affinity for receptor but no efficacy, so no effect.
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Competitive Antagonist?
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Competitive anatagonists compete with agonist for same receptor. Still produces max effect but needs higher doese (DECREASES POTENCY).
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Non-competitive Antagonist?
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Bonds to another receptor, not the same one as agonist. Even a higher dose can not produce max effect (DECREASE EFFICACY).
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Allosteric modulation?
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Allows manipulation of recpetor without blocking it. Can increase or decrease effect.
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