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Related Topics
Cards In This Set
| Front | Back |
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What are suppositories?
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Solid bodies of various weights and shapes adapted for insertion into rectal, vaginal or urethral orifices of the body.
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What systemic effects can suppositories provide?
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Antinauseant, antiasthmatic, analgesic, hormone.
Chloropromazine - tranquilizier ergotamine tartarate - migraine tx |
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What are some local examples of suppositories?
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Hydrocortisone - hemorrhoids
Glycerine - laxative |
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Which rectal veins go directly into the systemic blood flow?
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Middle and inferior hemorrhoidal veins
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How much do rectal suppositories weigh?
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2g, and are 2-3cm in length. Infant suppositories should weigh half of adult.
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How do vaginal suppositories get into systemic circulation?
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Through the vaginal artery.
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What is the shape of vaginal suppositories and their weight?
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Ovoid or Globular., 3-5g each.
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What type of base are vaginal suppositories compounded with?
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Water soluble to minimize leakage.
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What purposes do vaginal suppositories fill?
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Contraception, estrogenic, combat invading pathogens, antifungal, antibacterial.
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How long are urethral suppositories?
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50mm female, 2g
125mm male, 4g 5mm diameter for both |
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What are desirable properties for suppository bases?
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Stable under normal conditions
Compatible No odor Non Toxic Non Irritating Melt/dissolve inside body orifice mix/absorb water wetting/emulsifying properties |
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What are some oleaginous bases?
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Theobroma oil (cocoa butter)
Synthetic triglyceride mixturesHow m |
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What is the main form of cocoa butter?
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Beta
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What are the major factors with cocoa butter?
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Don't heat above 35 degrees
Melting point drops when adding certain drugs (chloral hydrate and phenol) beeswax raises mp Has no surfactant so can't emulsify water Need water-soluble form of drug |
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What are synthetic tricglycerides made up of?
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Hydrogenated Vegetable oils (palm, palm kernel, coconut oils)
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