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Cards In This Set
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What is the prototype drug for NSAIDS?
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Ibuprofen
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What is ibuprofen used for?
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Analgesic - mild to moderate pain
antipyretic - fever
anti-inflammatory
(dysmenorrhea)
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What is the brand name of ibuprofen?
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Advil
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What's the difference between ibuprofen and salicylates?
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Ibuprofen does not affect platements
It is a "non-aspirin" NSAID
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Ibuprofen is a nonaspirin NSAID and inhibits both COX-1 and COX-2 but it is a_________ inhibition, unlike salicylates.
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reversible
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What is the duration of ibuprofen?
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24 hours
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What is the difference in the peak time for analgesic and antipyretic effects vs. inflammatory effects?
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Analgesic/antipyretic -- 2-4hours
anti-inflammatory effects - few days-2 weeks
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METABOLISM
Ibuprofen is _________ protein bound and metabolized in the ____________. Half life is _______.
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Highly
liver
1.8 to 2 hours.
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How is ibuprofen excreted?
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Urinary excretion within 24 hours.
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What is the pharmacodynamics of NSAIDS - ibuprofen?
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REVERSIBLY inhibits cycooxygenase (COX)
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Ibuprofen has a _________ rather than _________ action as an analgesic.
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Peripheral
Central
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Are lower or higher doses required for an anti-inflammatory effect?
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Higher
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What are the major contraindications of NSAIDS - ibuprofen?
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Liver disease & Renal disease - caution with renal or hepatic impairment
Coagulopathy or hemophilia/hemopoietic dysfunction
(because can affect some of blood clotting cascade still, but different than aspirin)
Active GI disease - (drinkers and smokers more at risk for GI adverse effects)
Cardiac impairment
Age >60 yrs
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What is the pregnancy category for NSAIDS - ibuprofen?
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Category B, but category D in 3rd trimester
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All NSAIDS have a black box warning that they may increase the rik of serious and potentially fatal ___________ such as __________. RIsk increases with __________.
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CV thrombotic events
MI/CVA
duration of use
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