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Cards In This Set
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Eclipse period?
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When the virus first infects the cell and hides for a bit
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Cytopathic effect?
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CPE: the morphological changes that indicate a cell's infected with virus; can be seen with a lab microscope
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Inclusion bodies?
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Sites inside cells where viruses are replicating; could be nucleus or cytoplasm
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Neutralization?
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When you get a virion and its antibody together, they bind really tightly and the virion can't infect; this is a lab test to ID viruses. won't see cytopathic effects or PFU
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Seroconversion?
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When serum from an acute illness is compared with convalescent serum, there's a change in antibody status (going from being seronegative to seropositive)
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Window period/window phase?
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When a person should have detectable viral infection or antibody, but they don't yet (later in convalescence specific Abs appear)
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2 ways to get a rapid viral diagnosis?
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1. protein antigens using fluorescent Ab
2. nucleic acid using PCR |
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Icosahedral has X sides?
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20
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Basic building blocks for virus particles?
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Identical capsomers. for naked viruses, these are the antigens that react with Ab.
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Which Ig defends against viruses in the respiratory and GI tracts?
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IgA
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What do all naked RNA viruses have in common? hint: 2 things about shape and assembly
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1. they're icosahedral
2. they're assembled in cell cytoplasm |
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Two classes of naked RNA viruses?
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1. picornavirus (polio)
2. reovirus (infant diarrhea) |
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What do all naked DNA viruses have in common? hint: 2 things about shape and assembly
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1. they're icosahedral
2. they're assembled in the nucleus |
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Which class of virus is generally stable and can be transmitted without direct person to person contact?
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Simple (naked) nucleocapsid viruses
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Host range?
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Species that can be infected; determined by the receptor proteins in host cell membranes
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